I have been on 400 mg of Tramadol a day for some years to eliminate neuropathy pain in my feet due to diabetes. The only negative effect I can report is constipation which occurs with any opioid.
If I Take Codeine 500mg Of Tramadol A Day, What Would Be Long Term Effects On My Body?
I am not sure how long ago this was posted but the answer is YES, it can have long term effects. The thing about tramadol is it's barely an opioid and only 1 of 5 active metabolites has any opioid activity, it just so happens this activity occurs at the mu-opioid receptor which is the one that provides pain relief and euphoria, it does not bind to the other ones delta and kappa.
Tramadol is chemically related to venlafaxine (the SNRI antidepressant), in fact the two molecules are nearly identical, except venlafaxine has no opioid activity at all. Tramadol has prominent SNRI properties (like that of venlafaxine) so it can cause changes in the brain chemistry which could be beneficial if chronic pain is causing some degree of depression .
However the biggest risk associated with tramadol is seizures, tramadol lowers the seizure threshold and if taken with other antidepressants (SSRI and tricyclic antidepressants) this could further reduce seizure threshold.
Tramadol is being prescribed left right and centre because doctors believe it has lower abuse potential and is not as addictive which I think is going to come back and cause problems. I say this because the opioid activity WILL cause dependence and we now know that SSRI and/or SNRI antidepressants can cause withdrawal symptoms too, so it could be a double edged sword.
Tramadol is chemically related to venlafaxine (the SNRI antidepressant), in fact the two molecules are nearly identical, except venlafaxine has no opioid activity at all. Tramadol has prominent SNRI properties (like that of venlafaxine) so it can cause changes in the brain chemistry which could be beneficial if chronic pain is causing some degree of depression .
However the biggest risk associated with tramadol is seizures, tramadol lowers the seizure threshold and if taken with other antidepressants (SSRI and tricyclic antidepressants) this could further reduce seizure threshold.
Tramadol is being prescribed left right and centre because doctors believe it has lower abuse potential and is not as addictive which I think is going to come back and cause problems. I say this because the opioid activity WILL cause dependence and we now know that SSRI and/or SNRI antidepressants can cause withdrawal symptoms too, so it could be a double edged sword.
It would surly make you fell good ..thats for sure other then that it will have no long term anything.. Take care.
