Generally, caffeine (in energy drinks) does not interfere with antidepressants. For example, commonly prescribed SSRIs and caffeine have no negative interaction, according to Drugs.com's interaction checker. Caffeine can, however, raise blood pressure. Certain antidepressants, such as venlafaxine, sold as Effexor, also raise blood pressure, so avoid caffeine when taking this medication. If you feel anxious or restless from your antidepressant, caffeine can worsen those side effects. If your antidepressants cause sedation, a small amount of caffeine can help alleviate the effects.