The time Suboxone takes to leave the system is relatively unstudied. After one dose, the plasma half-life is around 37 hours, and under normal circumstances, drug advisors would say that a drug would leave the system in seven half-lives. However, Suboxone (Buprenorphine) doesn’t work like most drugs; it is a multi-compartment system that is highly fat-soluble, so it is absorbed into the fat cells, nervous system and plasma protein in the blood.
This adds a new variable into the equation - the greater the percentage of fat in the body, the greater the potential for absorption, and the longer it is likely to take to completely clear the system.
It also builds up in the system over time, so the longer you’ve been taking it, the longer it will take to clear your system completely. One Suboxone user on www.drugs.com who took around 2 mg per day for three years before being made to discontinue taking the drug for 13 days. Blood work at this point revealed he still had more than a quarter of the steady-state dosage in his body, though he pointed out that he had more than 11 per cent body fat. He also estimated that taking 4 mg daily for six months with just 11 per cent body fat, one should leave a minimum of 17 days for the drug to completely leave the system.
However, doctors advise that Suboxone is not for occasional use, and you should not stop taking Suboxone without first talking to your doctor, as they may wish to gradually reduce your dosage, to minimise withdrawal symptoms.
This adds a new variable into the equation - the greater the percentage of fat in the body, the greater the potential for absorption, and the longer it is likely to take to completely clear the system.
It also builds up in the system over time, so the longer you’ve been taking it, the longer it will take to clear your system completely. One Suboxone user on www.drugs.com who took around 2 mg per day for three years before being made to discontinue taking the drug for 13 days. Blood work at this point revealed he still had more than a quarter of the steady-state dosage in his body, though he pointed out that he had more than 11 per cent body fat. He also estimated that taking 4 mg daily for six months with just 11 per cent body fat, one should leave a minimum of 17 days for the drug to completely leave the system.
However, doctors advise that Suboxone is not for occasional use, and you should not stop taking Suboxone without first talking to your doctor, as they may wish to gradually reduce your dosage, to minimise withdrawal symptoms.