Don't worry, you will definitely feel it. First of all, your periods become irregular. It's the first sign of menopause. Next, you can experience a lot of symptoms such as hot flashes, insomnia, weight gain, mood swings, fatigue, and many more. Personally, I experienced hot flashes and vaginal dryness. Premarin Cream was a real find for me. It helped to get rid of itching and come back to normal sex life.