Methylphenidate also known as concerta is a psycho stimulant drug approved for the treatment of attention-deficit hyperactivity disorder, postural orthostatic tachycardia syndrome, and narcolepsy. It may also be prescribed for off-label use in treatment-resistant cases of lethargy, depression, neural insult and obesity. Methylphenidate belongs to the piperidine class of compounds and increases the levels of dopamine and nor-epinephrine in the brain through reuptake inhibition of the monoamine transporters. Methylphenidate possesses structural similarities to amphetamine and its pharmacological effects are more similar to those of cocaine, though MPH is less potent and longer in duration of action, remaining in your system for up to 96 hours.
Methylphenidate has high potential for abuse and addiction due to its pharmacological similarity to cocaine and amphetamines. Methylphenidate, like other stimulants, increases dopamine levels in the brain, but at therapeutic doses this increase is slow, and therfore euphoria does not typically occur except in rare cases. The abuse potential is increased when methylphenidate is crushed and snorted or when it is injected, producing effects almost identical to cocaine. Cocaine-like effects can also occur when very large doses are taken orally. However, the dosage amount that produces euphoric effects varies between individuals. Methylphenidate is actually more potent than cocaine in its effect on dopamine transporters. Methylphenidate should not be viewed as a weak stimulant as has previously been hypothesized.
The primary source of methylphenidate for abuse is diversion from legitimate prescriptions, rather than illicit synthesis. Those who use it to stay awake do so by taking it orally, while intranasal and intravenous are the preferred means for inducing euphoria. IV users tend to be adults whose use may cause pan-lobular pulmonary emphysema.
Abuse of prescription stimulants is higher amongst college students than non-college attending young adults. College students use methylphenidate either as a study aid or to stay awake longer. Increased alcohol consumption due to stimulant misuse has additional negative effects on health. Methylphenidate's pharmacological effect on the central nervous system is almost identical to that of cocaine. Studies have shown that the two drugs are nearly indistinguishable when administered intravenously to cocaine addicts.
Methylphenidate has high potential for abuse and addiction due to its pharmacological similarity to cocaine and amphetamines. Methylphenidate, like other stimulants, increases dopamine levels in the brain, but at therapeutic doses this increase is slow, and therfore euphoria does not typically occur except in rare cases. The abuse potential is increased when methylphenidate is crushed and snorted or when it is injected, producing effects almost identical to cocaine. Cocaine-like effects can also occur when very large doses are taken orally. However, the dosage amount that produces euphoric effects varies between individuals. Methylphenidate is actually more potent than cocaine in its effect on dopamine transporters. Methylphenidate should not be viewed as a weak stimulant as has previously been hypothesized.
The primary source of methylphenidate for abuse is diversion from legitimate prescriptions, rather than illicit synthesis. Those who use it to stay awake do so by taking it orally, while intranasal and intravenous are the preferred means for inducing euphoria. IV users tend to be adults whose use may cause pan-lobular pulmonary emphysema.
Abuse of prescription stimulants is higher amongst college students than non-college attending young adults. College students use methylphenidate either as a study aid or to stay awake longer. Increased alcohol consumption due to stimulant misuse has additional negative effects on health. Methylphenidate's pharmacological effect on the central nervous system is almost identical to that of cocaine. Studies have shown that the two drugs are nearly indistinguishable when administered intravenously to cocaine addicts.
