Lighter weight and many reps always worked for me - I wasn't about to enter a weightlifting contest (and I didn't want to risk musculo-skeletal damage that would come back to kick me in later life).
The old approach used to be to first build the muscles that you wish to refine.
I would assume that is still a good approach.
Nevertheless, here's two sites you may wish to visit:
http://www.bodybuilding.com/fun/high-reps-low-reps-which-rep-scheme-is-best.html
www.shape.com/celebrities/star-trainers/ask-celebrity-traine