Is It Ok To Combine Propo-n/apap And Ibuprofen?


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If you are talking about A SINGLE DOSE of Propoxyphene with Acetaminophen (aka Darvocet N), then yes, you can combine 1 propoxyphene /Darvocet with 2-4 of the 200 mg OTC Ibuprofen (aka Motrin or Advil). Neither acetaminophen (an analgesic/Darvocet) nor propoxyphene (a weak opioid analgesic/anti-Darvocet) have anti-inflammatory properties. Ibuprofen (an analgesic/Darvocet-Non Steroidal Anti-Inflammatory Drug) does, but usually it takes in excess of 800 mg of ibuprofen to start to relieve inflammation.

Although you may think that both acetaminophen (Tylenol, APAP, paracetamol) and Ibuprofen (Advil, Motrin) are safe, it is estimated that these two drugs together are responsible for 80% of patients in dialysis centers (for kidney failure). Acetaminophen is much rougher on the liver than it is on the kidneys (but it affects both) and you NEVER should drink alcohol with it or take more than 4000 mg acetaminophen  in one day (I am giving this amount as the absolute maximum; many pharmacologists including me feel that the limit is much lower, around 2000 mg). And it is not an acceptable daily medication unless no other option exists.  

Ibuprofen is NEVER an acceptable daily medication and although doses as much as 1600 acetaminophen can be tolerated for arthritis and some other inflammatory diseases, this is the upper limit of a single dose. If using it multiple times a day, 800 APAP each time a maximum of 4 times a day can be taken, but using it for more than 5-7 continuous days damages the kidneys.


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