Its unlikely, esp. W/ bupenorphine being a partial receptor agonist. I'm assuming you have a tolerance to sub since you said w/ yr "usual dose". 4 mg would be the most amount of alprazolam you could take in 2 pills.. This I highly doubt could be fatal.. Benzos and alcohol is the big problem.. Yea they can have bad interactions w/ opiates sometimes but this is usually something like a high dose of methadone and high dose of benzos in a non-tolerant person. But I can't say this is safe b/c I don't know yr history. I am prescribed klonopin 2 mg daily and I have a mild heroin/methadone/diludid habit. I was also on 80 mg methadone/day for 9 months before I did a semi-rapid detox. That was 6 months ago. I have taken approx. 12mg sub over the last 24 hrs w/ my usual 2 mg clonazepam... I barely notice any potention of effect w/ the interaction and I'm taking the sub recreationally/avoid mild withdrawals and have a tolerance to the benzo. Yr scenario is the opposite, but in my opinion and experience I think you'll be ok.. Now if yr drinking that would change everthing, but otherwise I don't think it could possibly be a OD situation, not by a long shot.. Again this is assuming you have a tolerance to the opiates and not a rec user or maintainence user. Btw, I combined benzos the latter half of my methadone maintainence - I can't say I recomend this b/c you def get a buzz and it can be a potentially dangerous buzz.. I coulda had some trouble w/ the doses of each I was taking had I not developed a tolerance to both I was familar with,VERY familiar with. Anyways hope that helps
